Pittsburgh took their fifth consecutive win.
The quarterback increased his career total for touchdown passes to 350, surpassing Eli Manning for the seventh most in NFL history.
He also completed 22 of 25 throws for 328 yards and achieved a perfect 158.3 passer rating during the game.
James Conner ran for 65 yards and a score, while Antonio Brown had eight receptions for 96 yards as the Steelers snapped the Panthers’ three-game winning streak.
Pittsburgh’s win improved the team’s record to 6-2-1 for the season and kept them atop the AFC North standings.
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